Cart
sales@molnova.com
Tazemetostat hydrobromide
CAS No. 1467052-75-0
Tazemetostat hydrobromide ( EPZ-6438 hydrobromide; E-7438 hydrobromide )
Catalog No. M26837 CAS No. 1467052-75-0
Tazemetostat hydrobromide is a potent and selective EZH2 inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 32 | In Stock |
|
| 5MG | 50 | In Stock |
|
| 10MG | 67 | In Stock |
|
| 50MG | 87 | In Stock |
|
| 100MG | 146 | In Stock |
|
| 200MG | 219 | In Stock |
|
| 500MG | 357 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTazemetostat hydrobromide
-
NoteResearch use only, not for human use.
-
Brief DescriptionTazemetostat hydrobromide is a potent and selective EZH2 inhibitor.
-
DescriptionTazemetostat hydrobromide is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 (Ki: 2.5 nM). Tazemetostat hydrobromide also inhibits EZH1 (IC50: 392 nM).(In Vitro):Tazemetostat hydrobromide inhibits Rat EZH2 (IC50: 4 nM). Tazemetostat hydrobromide inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat hydrobromide inhibits multi wild-type and mutant lymphoma cell lines proliferation with IC50s of 0.49 nM-7.6 μM .(In Vivo):Tazemetostat (250 or 500 mg/kg twice daily for 21-28 days) practically eliminates the fast-growing G401 tumors .
-
SynonymsEPZ-6438 hydrobromide; E-7438 hydrobromide
-
PathwayChromatin/Epigenetic
-
TargetHistone Demethylase
-
Recptormicrotubule
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1467052-75-0
-
Formula Weight653.7
-
Molecular FormulaC34H45BrN4O4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESBr.CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Ekaterina Poluektova, et al. Curvulin and Phaeosphaeride A From Paraphoma Sp. VIZR 1.46 Isolated From Cirsium arvense as Potential Herbicides. Molecules. 2018 Oct 28;23(11):2795.
molnova catalog
related products
-
SNDX-5613
SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM).
-
D-alpha-Hydroxygluta...
A competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
-
JIB-04
JIB-04 is a pan-selective Jumonji histone demethylase inhibitor.
